Rivaroxaban 366789-02-8

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Rivaroxaban'ın temel bilgileri:

Name	Rivaroxaban
Alias	(S)-Rivaroxaban;(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carbox;RIVAROXABAN STAGE-IV [5-CHLORO-N-({5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2(AS PER INV;Rivaroxaban Isomer;5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide;BAY 59-7939; 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
CAS NO.	366789-02-8
Molecular Formula	C19H18ClN3O5S
Molecular Weight	435.88
Brief Introduction	Rivaroxaban is an oral, bioavailable Factor Xa inhibitor that selectively blocks the active site of Factor Xa and does not require a cofactor (eg, antithrombin III) to exert activity. Activation of factor X by factor Xa (FXa) by endogenous and exogenous pathways plays an important role in the coagulation cascade. Rivaroxaban dose-dependently inhibits factor Xa activity in humans, with dose-dependent prolongation of prothrombin time (PT), activated partial thromboplastin time (aPTT), and HepTest® heparin quantitative determination using Neoplastin® reagent. Anti-factor Xa activity is also affected by rivaroxaban.
Storage condition	Room temperature, seal.

Venöz tromboemboliyi (VTE) önlemek için elektif kalça veya diz protezi ameliyatı geçiren erişkin hastalar

Items	Standard	Results
Appearance	White or almost white powder	White powder
Melting point	229~ 234℃	230.0~231.5℃
Residue on ignition	NMT0.1%	0.03%
Related substances	Any other impurity: NMT0.2% Total of impurity: NMT0.5 %	0.1% 0.19%
Loss on drying	NMT1.0%	0.13%
Heavy metal	NMT20ppm	Conforms
Purity	More than 99.50%	99.81%
Conclusion: The results show that the product complies with the Enterprise standard.

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Name	Rivaroxaban
Alias	(S)-Rivaroxaban;(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carbox;RIVAROXABAN STAGE-IV [5-CHLORO-N-({5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2(AS PER INV;Rivaroxaban Isomer;5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide;BAY 59-7939; 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
CAS NO.	366789-02-8
Molecular Formula	C19H18ClN3O5S
Molecular Weight	435.88
Brief Introduction	Rivaroxaban is an oral, bioavailable Factor Xa inhibitor that selectively blocks the active site of Factor Xa and does not require a cofactor (eg, antithrombin III) to exert activity. Activation of factor X by factor Xa (FXa) by endogenous and exogenous pathways plays an important role in the coagulation cascade. Rivaroxaban dose-dependently inhibits factor Xa activity in humans, with dose-dependent prolongation of prothrombin time (PT), activated partial thromboplastin time (aPTT), and HepTest® heparin quantitative determination using Neoplastin® reagent. Anti-factor Xa activity is also affected by rivaroxaban.
Storage condition	Room temperature, seal.

Venöz tromboemboliyi (VTE) önlemek için elektif kalça veya diz protezi ameliyatı geçiren erişkin hastalar

Items	Standard	Results
Appearance	White or almost white powder	White powder
Melting point	229~ 234℃	230.0~231.5℃
Residue on ignition	NMT0.1%	0.03%
Related substances	Any other impurity: NMT0.2% Total of impurity: NMT0.5 %	0.1% 0.19%
Loss on drying	NMT1.0%	0.13%
Heavy metal	NMT20ppm	Conforms
Purity	More than 99.50%	99.81%
Conclusion: The results show that the product complies with the Enterprise standard.

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